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Hair regenerative activities of flavonoid-rich extract of Equisetum hyemale L. (Equisetaceae) in chemically-induced alopecia in Sprague Dawley rats


Article published in Journal of Pharmacy & Pharmacognosy Research 7(5): 323-330, 2019.

Penuel P. David1,2*, Cecilia D. Santiago1,3, Anges L. Castillo4, Gerard Q. De Guzman1,3,5,6,7

1Graduate School, Centro Escolar University, Manila, Philippines.2Department of Pharmacy, Centro Escolar University, Malolos, Philippines.3School of Pharmacy, Centro Escolar University, Manila, Philippines.4Faculty of Pharmacy and the Graduate School, University of Santo Tomas, Manila, Philippines.5College of Pharmacy and Graduate School, Adamson University, Manila, Philippines.6Francisco Q. Duque Medical Foundation, College of Medicine, Lyceum Northwestern University, Dagupan, Pangasinan, Philippines. 7The Graduate School, Virgen Milagrosa University Foundation, San Carlos, Pangasinan, Philippines.*E-mail: pdavid@ceu.edu.ph

Abstract

Context: The prevalence of alopecia around the world is high and awareness continuously increased due to social stigma. There are limited commercially-available medications for the management of different forms of baldness, most of which are prohibitively expensive and presents with various adverse effects.

Aims: To evaluate the flavonoid-rich ethyl acetate extract of Equisetum hyemale stem for its hair-regenerative properties in chemically-induced alopecia in Sprague Dawley rats.

Methods: Various concentrations of the flavonoid-rich extract of E. hyemale were applied in depilated areas in dorsal rat skin after chemical induction of alopecia. Evidence of hair growth was observed for 28 days in a weekly basis. Histopathological analysis of rat skin was performed to demonstrate evidence of follicular hair growth.

Results: The abundance of flavonoids in the ethyl acetate extract was established by total flavonoid contents and LC-MS analyses. The 2.5% E. hyemale extract exhibited hair-regenerative properties with high tensile strengths, combined masses and follicular growth, which was comparable to the positive control, 5% minoxidil (p>0.05). The highest rate of hair follicular development was observed in the telogen phase in rat skin after 28 days of treatment.

Conclusions: The flavonoid-rich ethyl acetate extract of E. hyemale exhibits in situ hair-regenerative properties in chemically-induced alopecia in rats at 2.5% w/v concentration.

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Información

Esta entrada fue publicada el 2 de septiembre de 2019 por en Alopecia, Analytical Chemistry, Flavonoids, Natural products, Preclinical Research, Rats.

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