For specialists working in the pharmaceutical and herbal fields
Article published in J. Pharm. Pharmacogn. Res., vol. 12, no. 1, pp. 39-49, Jan-Feb 2024.
DOI: https://doi.org/10.56499/jppres23.1726_12.1.39
Original Article
1Department of Biochemistry, Faculty of Medicine, Universitas Sumatera Utara, Medan 20155, Indonesia.
2Department of Dermatology & Venereology, Faculty of Medicine, Universitas Sumatera Utara, Medan 20155, Indonesia.
3Department of Ear, Nose & Throat, Head & Neck, Faculty of Medicine, Universitas Sumatera Utara, Medan 20155, Indonesia.
4Stem Cell and Cancer Research, Faculty of Medicine, Universitas Islam Sultan Agung, Semarang 50112, Indonesia.
5Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Jenderal Achmad Yani, Bandung 40513, Indonesia.
6Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan 20155, Indonesia.
7Department of Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan 20155, Indonesia.
*E-mail: mutiara@usu.ac.id
Abstract
Context: With recent biochemical studies, inflammation has been considered a therapeutic target. Mesenchymal stem cells are considered a therapeutic option because of the immunomodulatory effects of their bioactive factors, the secretome.
Aims: To systematically review the potential of mesenchymal stem cell secretome therapy on inflammation through its effects on biomarker characteristics, organ damage, and survival rate.
Methods: This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement. A literature search was performed in PubMed, ScienceDirect, and ProQuest, and through citation searching for records published in the last ten years. The eligibility criteria of the identified study as follows: Population (P): Human, animal, or in vitro models with inflammatory disease; Intervention (I): Stem cell secretome administration; (C): Healthy human, animal, or in vitro models; and Outcome (O): Inflammatory biomarker statistics, organ injury, or survival rate. AXIS tool was used to assess the quality of the records.
Results: 3,258 records were found. The duplicates and undesired articles were excluded with automation tools. 38 relevant records were further identified through citation searching. The screening and exclusion of records based on the inclusion and exclusion criteria left 24 eligible studies. The studies show that secretome improves the biomarker characteristics by reducing proinflammatory cytokines levels while increasing anti-inflammatory cytokines levels. Many studies show that secretome also improved organ injury and survival rate.
Conclusions: Secretome alleviates inflammation with its immunomodulatory effects, which may be associated with improvements in organ injury and overall outcome.
Un modelo, miles de editores, múltiples plataformas.
Buenas Prácticas Farmacéuticas Mercosur
Educa tu alimentación
Un blog de física médica para todos los públicos
Asociación de Familiares de Enfermos de Alzheimer y otras Demencias Neurodegenerativas de Lugo
El placer no es bueno, ni malo, simplemente existe. Gastronomía, vinos, viajes, ocio, cultura, life style, tendencias todo es hedonismo.
Just another WordPress.com site
Un patio para dar a conocer infinidad de cervezas y difundir la auténtica cultura cervecera.
La fotografía es la mejor compañía de las historias
El blog de Carlos Pazos. Grafismos, viñetas de humor sobre ciencia, tecnología y todo lo que mola saber.
Alternativas para vivir con plenitud, simplicidad, armonía y propósito.
Nunca antes la ciencia fue tan fácil
En sintonía con la realidad
No te pierdas lo que dice la ciencia
La actualidad científica a tu alcance.
For specialists working in the pharmaceutical and herbal fields